Qualitative Comparison of Metoclopramide, Ondansetron and Granisetron Alone and in Combination with Dexamethasone in the Prevention of Postoperative Nausea and Vomiting in Day Care Laparoscopic Gynaecological Surgery under General Anaesthesia

AIM: To compare qualitatively Metoclopramide, Ondansetron and Granisetron alone and in combination with Dexamethasone in the Prevention of Postoperative Nausea and Vomiting in Day Care Laparoscopic Gynaecological Surgery under General Anaesthesia. METHOD: 180 adult female patients of ASA Grade I and II, BMI <30, aged 18 to 55 years undergoing laparoscopic gynaecological surgery under general anaesthesia included in the study. Patients with history of motion sickness and past history of PONV were excluded from the study. The study was carried out in six groups consisting of randomly selected 30 patients in each. Before induction of general anaesthesia, the antiemetic drugs under study given intravenously i.e. Metoclopramide (10 mg), Ondansteron (4mg) and Granisetron (3 mg) were given alone in group A, B and C respectively while in group D, E and F these drugs were combined with Dexamethasone (8 mg) respectively. The study drugs were given as intravenous injections. RESULT: The study found that Metoclopramide is very poor because of higher incidence of side effects and only 36.7% success rate in the prevention of PONV. The success rate in the prevention of PONV is poor in Ondansetron & Granisetron (nearly two-third, 63.3% & 66.7% respectively). The success rate found good (nearly three-fourth, 73.3%) in combination of Metoclopramide with Dexamethasone and very good in combination of Ondansetron & Granisetron with Dexamethasone (90% in both).